Triethylamine → 4-{[(2-Methoxy-ethyl)-methyl-amino]-methyl}-N-(4-methoxy-7-phenyl-benzooxazol-2-yl)-benzamide

HRID 1611936Notes

Reaction equation

HRID 1611936 reaction equation
[CH3:1][O:2][C:3]1[C:8]2[N:9]=[C:10]([NH2:12])[O:11][C:7]=2[C:6]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[CH:5][CH:4]=1.[CH3:19][O:20][CH2:21][CH2:22][N:23]([CH2:25][C:26]1[CH:34]=[CH:33][C:29]([C:30](Cl)=[O:31])=[CH:28][CH:27]=1)[CH3:24].C(N(CC)CC)C>CN(C1C=CN=CC=1)C.C1COCC1>[CH3:19][O:20][CH2:21][CH2:22][N:23]([CH2:25][C:26]1[CH:27]=[CH:28][C:29]([C:30]([NH:12][C:10]2[O:11][C:7]3[C:6]([C:13]4[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=4)=[CH:5][CH:4]=[C:3]([O:2][CH3:1])[C:8]=3[N:9]=2)=[O:31])=[CH:33][CH:34]=1)[CH3:24]

Participants

6

Reactant 3

HCID 8471TriethylamineHCID 222522314-Methoxy-7-phenyl-benzooxazol-2-ylamineHCID 222522414-{[(2-Methoxy-ethyl)-methyl-amino]-methyl}-benzoyl chloride

Product 1

HCID 103662344-{[(2-Methoxy-ethyl)-methyl-amino]-methyl}-N-(4-methoxy-7-phenyl-benzooxazol-2-yl)-benzamide

Reagents, catalysts & solvents 2

HCID 142844-(Dimethylamino)pyridineCatalystHCID 8028TetrahydrofuranSolvent

Procedure

From 4-methoxy-7-phenyl-benzooxazol-2-yl-amine with 4-{[(2-methoxy-ethyl)-methyl-amino]-methyl}-benzoyl chloride, triethylamine and N,N-dimethyl-4-aminopyridine in THF. ES-MS m/e (%): 446 (M+H+, 100).

Sources & evidence

ORD record
ord-e165d822e4d44a2296266f131cb0d67f
Source dataset
uspto-grants-2006_01
Patent number
US06992083B2

Reaction notes

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