Hydrochloric Acid → HCID 68154283, compound

HRID 1615764Notes

Reaction equation

HRID 1615764 reaction equation
[OH-].[Li+].[F:3][C:4]1[CH:5]=[C:6]([CH:11]2[CH2:16][N:15]([C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])[CH:14]([CH:24]3[CH2:29][CH2:28][O:27][CH2:26][CH2:25]3)[C:13](=[O:30])[N:12]2[CH2:31][C:32]([O:34]C)=[O:33])[CH:7]=[C:8]([F:10])[CH:9]=1.Cl>C1COCC1.O>[C:20]([O:19][C:17]([N:15]1[CH2:16][CH:11]([C:6]2[CH:5]=[C:4]([F:3])[CH:9]=[C:8]([F:10])[CH:7]=2)[N:12]([CH2:31][C:32]([OH:34])=[O:33])[C:13](=[O:30])[CH:14]1[CH:24]1[CH2:25][CH2:26][O:27][CH2:28][CH2:29]1)=[O:18])([CH3:23])([CH3:21])[CH3:22]

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 68154662HCID 68154662, compound2×

Product 1

HCID 68154283HCID 68154283, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Procedure

12 mg (0.48 mmol) lithium hydroxide were added to 0.20 g (0.43 mmol) tert-butyl 5-(3,5-difluorophenyl)-4-(2-methoxy-2-oxoethyl)-3-oxo-2-(tetrahydro-2H-pyran-4-yl)piperazine-1-carboxylate (isomer mixture 2.1) in 5 ml THF and 1 ml of water. The mixture was stirred for 2 h at RT, adjusted to pH=7 with 0.1 M hydrochloric acid solution and then evaporated to dryness.

Workup

  1. customevaporated to dryness

Sources & evidence

ORD record
ord-d0be47809658475f802fbaa94611d8fb
Source dataset
uspto-grants-2014_07
Patent number
US08765763B2

Reaction notes

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