反应详情

In analogy to example 161, step 1, 5-(3-(4-chloro-2-methylphenyl)-3-(4-(methylsulfonyl)phenyl)propanoyl)pyridin-2(1H)-one (example 339, step 2) was reacted with 1-bromo-2-methoxyethane in the presence of potassium carbonate and a catalytic amount of tetrabutylammonium iodide. The product of this reaction was reacted in analogy to example 151, step 3, with hydroxylamine hydrochloride in the presence of sodium hydrogencarbonate to give the title compound as a colourless solid containing less than 10% of the corresponding Z isomer, MS (ESI+): m/z=503.2 [M+H]+.