Hydrochloric Acid → HCID 68108650, compound

HRID 1623673Notes

Reaction equation

HRID 1623673 reaction equation
[Li+].[OH-].[CH3:3][N:4]1[CH2:9][CH2:8][N:7]([C:10]([C:12]2[CH:13]=[CH:14][C:15]([O:22][CH2:23][C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)=[C:16]([CH:21]=2)[C:17]([O:19]C)=[O:18])=[O:11])[CH2:6][CH2:5]1.Cl>O.O1CCCC1>[CH3:3][N:4]1[CH2:5][CH2:6][N:7]([C:10]([C:12]2[CH:13]=[CH:14][C:15]([O:22][CH2:23][C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)=[C:16]([CH:21]=2)[C:17]([OH:19])=[O:18])=[O:11])[CH2:8][CH2:9]1

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 67107994HCID 67107994, compound

Product 1

HCID 68108650HCID 68108650, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Procedure

A solution of LiOH (393 mg, 9.36 mmol) in water (10 ml) was added to a stirred solution of methyl 5-[(4-methyl-1-piperazinyl)carbonyl]-2-[(phenylmethyl)oxy]benzoate (may be prepared as described in Description 50; 345 mg, 0.94 mmol) in tetrahydrofuran (2.5 ml) at room temperature. The mixture was stirred at room temperature for 3 h. The mixture was acidified by HCl (6 mol/L). The solvent was evaporated in vacuo to afford the crude product. The crude product was used directly in the next step without further purification.

Workup

  1. customThe solvent was evaporated in vacuo

Sources & evidence

ORD record
ord-c3b266c1932b45f0842b121a8ad5eb55
Source dataset
uspto-grants-2014_07
Patent number
US08778939B2

Reaction notes

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