1,2-Dichloroethane → HCID 68107702, compound

HRID 1623753Notes

Reaction equation

HRID 1623753 reaction equation
[F:1][C:2]1[CH:3]=[CH:4][C:5]([O:11][CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[C:6]([CH:10]=1)[C:7]([OH:9])=O.[N:19]1[CH:24]=[CH:23][CH:22]=[C:21]([NH2:25])[CH:20]=1.C1C=CC2N(O)N=NC=2C=1.C(Cl)CCl>CN(C=O)C.O>[F:1][C:2]1[CH:3]=[CH:4][C:5]([O:11][CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[C:6]([CH:10]=1)[C:7]([NH:25][C:21]1[CH:20]=[N:19][CH:24]=[CH:23][CH:22]=1)=[O:9]

Participants

7

Reactant 4

HCID 111,2-DichloroethaneHCID 100093-AminopyridineHCID 757711-HydroxybenzotriazoleHCID 22662041HCID 22662041, compound

Product 1

HCID 68107702HCID 68107702, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6228DimethylformamideSolvent

Procedure

A solution of 5-fluoro-2-[(phenylmethyl)oxy]benzoic acid (may be prepared as described in Description 20, 180 mg, 0.73 mmol), 3-pyridinamine (68.8 mg, 0.73 mmol), HOBT (134 mg, 0.88 mmol) and EDC (168 mg, 0.88 mmol) in DMF (10 ml) was stirred at room temperature overnight. Water (30 ml) was added and the mixture was filtered. The residue was dried to yield the title compound as a white solid. 100 mg.

Workup

  1. filtrationthe mixture was filtered
  2. customThe residue was dried

Sources & evidence

ORD record
ord-f99307c09b99442ead4a5efcebcdd07e
Source dataset
uspto-grants-2014_07
Patent number
US08778939B2

Reaction notes

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