反应详情

Diisopropylethylamine (0.97 ml, 5.55 mmol), 3-aminopyridine (418 mg, 4.44 mmol) and HATU (1.27 g, 3.33 mmol) were added to a solution of 5-acetyl-2-[(phenylmethyl)oxy]benzoic acid (commercially available from Acros; 600 mg, 2.22 mmol) in dimethylformamide (10 ml). The solution was stirred for 2 hours. Ethyl acetate (40 ml) and H2O (40 ml) were added and the organic layer washed with H2O (3×20 ml), dried and the solvent removed in vacuo to give a solid. Trituration with 3:1 hexane/ethyl acetate yielded the title compound as a yellow solid. 541 mg.

1. washthe organic layer washed with H2O (3×20 ml)
2. customdried
3. customthe solvent removed in vacuo
4. customto give a solid