Iodoethane → HCID 18680072, compound

HRID 1633874Notes

Reaction equation

HRID 1633874 reaction equation
[CH:1]([CH:4]1[C:13]2[C:8](=[CH:9][CH:10]=[C:11]([CH:14]3[CH2:16][CH:15]3[C:17]3[CH:18]=[C:19]4[C:24](=[CH:25][CH:26]=3)[CH:23]=[C:22]([C:27]#[N:28])[CH:21]=[CH:20]4)[CH:12]=2)[CH2:7][CH2:6][NH:5]1)([CH3:3])[CH3:2].[CH2:29](I)[CH3:30].C(N(CC)CC)C>C1COCC1>[CH2:29]([N:5]1[CH2:6][CH2:7][C:8]2[C:13](=[CH:12][C:11]([CH:14]3[CH2:16][CH:15]3[C:17]3[CH:18]=[C:19]4[C:24](=[CH:25][CH:26]=3)[CH:23]=[C:22]([C:27]#[N:28])[CH:21]=[CH:20]4)=[CH:10][CH:9]=2)[CH:4]1[CH:1]([CH3:3])[CH3:2])[CH3:30]

Participants

5

Reactant 3

HCID 6340IodoethaneHCID 8471TriethylamineHCID 18680150HCID 18680150, compound

Product 1

HCID 18680072HCID 18680072, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A solution of Example 20A (240 mg, 0.66 mmol), ethyl iodide (0.11 mL, 1.32 mmol), and triethylamine (0.18 mL, 1.32 mmol) in THF at 45° C. was stirred for 4 hours and concentrated. The concentrate was purified by flash column chromatography with 30% ethyl acetate/hexanes to provide the desired product.

Workup

  1. concentrationconcentrated
  2. customThe concentrate was purified by flash column chromatography with 30% ethyl acetate/hexanes

Sources & evidence

ORD record
ord-954fecc41ae74fa2afb6489d12931728
Source dataset
uspto-grants-2003_01
Patent number
US06504031B1

Reaction notes

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