Ammonia → Citalopram

To a stirred solution/suspension of 5-carboxyphthalide (57 mmol) and N,N,N′,N′-tetramethylethylenediamine (144 mmol) in THF (200 mL) was added a solution of p-fluorophenylmagnesium bromide (approx. 0.5 M) and magnesium bromide (approx 0.125 M) in THF dropwise until no more starting phthalide remained. A solution of 3-(N,N-dimethylamino)propylmagnesium chloride (approx. 2 M in THF/heptane) was added dropwise until no more of the previous intermediate remained. Methanesulfonyl chloride (228 mmol) was added dropwise over 5 minutes in an exothermic reaction . After 30 min, DMF (5 mL) was added, followed by POCl3 (228 mmol) dropwise over 10 minutes in a mildly exothermic reaction and the mixture was stirred for 2 h. t-Butylamine (285 mmol) was added dropwise over 15 minutes and the mixture was stirred overnight. DMF (5 mL) was added dropwise, followed by POCl3 (2.3 mol) over 1 h. The mixture was stirred overnight, and was then heated to reflux for 1 h. The mixture was cooled in and ice/water bath, and water (200 mL) was cautiously added dropwise over 1 h in an exothermic reaction. The mixture was basified to pH >9 with an aqueous solution of ammonia in water (25% w/v). Toluene (100 mL) was added, and the mixture was filtered. The residue was washed with further toluene, the combined filtrates were separated, and the organic phase was collected. The organic phase was extracted twice with an aqueous solution of H2SO4 (10 % v/v). The combined acid extracts were basified to pH >9 with an aqueous solution of ammonia in water (25% w/v) and were extracted with toluene. The combined toluene layers were dried and evaporated to give citalopram base as a dark oil. The oxalate salt was prepared using standard procedures to give citalopram oxalate. Yield 9.2 g. Purity (HPLC peak area) >90%.

1. additionwas added dropwise over 15 minutes
2. stirringThe mixture was stirred overnight
3. temperaturewas then heated
4. temperatureto reflux for 1 h
5. temperatureThe mixture was cooled in and ice/water bath
6. filtrationthe mixture was filtered
7. washThe residue was washed with further toluene
8. customthe combined filtrates were separated
9. customthe organic phase was collected
10. extractionThe organic phase was extracted twice with an aqueous solution of H2SO4 (10 % v/v)
11. extractionwere extracted with toluene
12. dry with materialThe combined toluene layers were dried
13. customevaporated

ORD record

ord-439c638f9b9846a3bf4c7c97206e95de

Source dataset

uspto-grants-2003_01

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06509483B2