2,2,2-Trifluoroethanol → 2-(2,2,2-Trifluoroethoxy)ethan-1-ol

HRID 1635803Notes

Reaction equation

HRID 1635803 reaction equation
[F:1][C:2]([F:6])([F:5])[CH2:3][OH:4].C1(=O)O[CH2:10][CH2:9][O:8]1.C(N(CC)CC)C>>[F:1][C:2]([F:6])([F:5])[CH2:3][O:4][CH2:10][CH2:9][OH:8]

Participants

4

Reactant 3

HCID 64092,2,2-TrifluoroethanolHCID 7303Ethylene carbonateHCID 8471Triethylamine

Product 1

HCID 2558542-(2,2,2-Trifluoroethoxy)ethan-1-ol

Procedure

A mixture of 36 ml (0.50 mol) of 2,2,2-trifluoroethanol, 66 g (0.75 mol) of ethylene carbonate and 70 ml (0.50 mol) of triethylamine was heated to reflux for 16 h. Distillation of the reaction mixture through a Vigreux column at normal pressure yielded the title compound as a colorless liquid.

Workup

  1. temperaturewas heated
  2. temperatureto reflux for 16 h
  3. distillationDistillation of the reaction mixture through a Vigreux column at normal pressure

Sources & evidence

ORD record
ord-49bb9723537d415885256fe9d7082d08
Source dataset
uspto-grants-2003_01
Patent number
US06511989B2

Reaction notes

Loading…