Tetrahydrofuran → 1-[4-(4-Chloro-2-fluoro-5-methoxyphenyl)-2-methylpiperazin-1-yl]-2-[3-(1,3-oxazol-2-yl)pyrazolo[5,4-b]pyridin-1-yl]ethanone
Reaction equation
[CH2:6]([Li:7])[CH2:8][CH2:9][CH3:10].[CH3:46][CH2:47][O:48][C:49](=[O:50])[CH3:51].[Cl:11][c:12]1[cH:13][c:14]([F:40])[c:15]([N:20]2[CH2:21][CH:22]([CH3:39])[N:23]([C:26]([CH2:27][n:28]3[n:29][c:30]([I:37])[c:31]4[c:32]3[n:33][cH:34][cH:35][cH:36]4)=[O:38])[CH2:24][CH2:25]2)[cH:16][c:17]1[O:18][CH3:19].[O:41]1[CH2:42][CH2:43][CH2:44][CH2:45]1.[Pd:128].[c:109]1([P:110]([c:111]2[cH:112][cH:113][cH:114][cH:115][cH:116]2)[c:117]2[cH:118][cH:119][cH:120][cH:121][cH:122]2)[cH:123][cH:124][cH:125][cH:126][cH:127]1.[c:52]1([P:53]([c:54]2[cH:55][cH:56][cH:57][cH:58][cH:59]2)[c:60]2[cH:61][cH:62][cH:63][cH:64][cH:65]2)[cH:66][cH:67][cH:68][cH:69][cH:70]1.[c:71]1([P:72]([c:73]2[cH:74][cH:75][cH:76][cH:77][cH:78]2)[c:79]2[cH:80][cH:81][cH:82][cH:83][cH:84]2)[cH:85][cH:86][cH:87][cH:88][cH:89]1.[c:90]1([P:91]([c:92]2[cH:93][cH:94][cH:95][cH:96][cH:97]2)[c:98]2[cH:99][cH:100][cH:101][cH:102][cH:103]2)[cH:104][cH:105][cH:106][cH:107][cH:108]1.[o:1]1[cH:2][n:3][cH:4][cH:5]1>>[o:1]1[c:2](-[c:30]2[n:29][n:28]([CH2:27][C:26]([N:23]3[CH:22]([CH3:39])[CH2:21][N:20]([c:15]4[c:14]([F:40])[cH:13][c:12]([Cl:11])[c:17]([O:18][CH3:19])[cH:16]4)[CH2:25][CH2:24]3)=[O:38])[c:32]3[c:31]2[cH:36][cH:35][cH:34][n:33]3)[n:3][cH:4][cH:5]1Participants
8
Reactant 7
Product 1
Sources & evidence
- ORD record
- ord-5e56ac8481884476b3ac0983edd412d7
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (9/10)
Reaction notes
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