Hydrochloric Acid → HCID 76849808, compound

HRID 1645255Notes

Reaction equation

HRID 1645255 reaction equation
[Cl:1][C:2]1[C:3]2[N:4]([C:8]([CH2:12][CH2:13][C:14]([O:16]CC)=[O:15])=[N:9][C:10]=2[I:11])[CH:5]=[CH:6][N:7]=1.[Li+].[OH-].Cl>O1CCCC1.C(O)C>[Cl:1][C:2]1[C:3]2[N:4]([C:8]([CH2:12][CH2:13][C:14]([OH:16])=[O:15])=[N:9][C:10]=2[I:11])[CH:5]=[CH:6][N:7]=1

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 87145489HCID 87145489, compound

Product 1

HCID 76849808HCID 76849808, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 8028TetrahydrofuranSolvent

Procedure

A solution of EXAMPLE 74A (1.96 g) in tetrahydrofuran (5 mL) and ethanol (1 mL) was treated with 2N LiOH (5.16 ml), stirred at room temperature for 3 hours and then neutralized to pH 3-4 with 3N HCl. The mixture was extracted with ethyl acetate. The extract was washed (brine), dried (MgSO4) and concentrated to dryness to give the title compound. MS (ESI(+)) m/e 352 (M+H)+.

Workup

  1. extractionThe mixture was extracted with ethyl acetate
  2. washThe extract was washed (brine)
  3. dry with materialdried (MgSO4)
  4. concentrationconcentrated to dryness

Sources & evidence

ORD record
ord-9cd0387c71514aceb48f5a0ec74c0b76
Source dataset
uspto-grants-2012_02
Patent number
US08124759B2

Reaction notes

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