反应详情

To a solution of methyl Z-4-[[2-butyl-5-[(1-butyl-2,5-dioxo-4-imidazolidinylidene)methyl]-1H-imidazol-1-yl]methyl]benzoate (1.00 g, 2.281 mmol) in DMF (10 mL) is added K2CO3 (1.580 g, 0.011 moles). After stirring for 15 minutes 4-chloromethyl-3,5-dimethylisoxazole (0.35 g, 2.39 mmol) is added. The mixture is stirred for 24 hours. The solvents were removed under high vacuum. After diluting with ethyl acetate and washing with water and brine the solution is dried over MgSO4. Evaporation in vacuo affords a viscous oil which is dissolved in ether and treated with ethereal HCl to afford a foamy solid upon evaporation in vacuo. This solid is crystallized from ethyl acetate/hexane.

1. additionis added
2. customThe solvents were removed under high vacuum
3. additionAfter diluting with ethyl acetate
4. washwashing with water and brine the solution
5. dry with materialis dried over MgSO4
6. customEvaporation in vacuo
7. customaffords a viscous oil which
8. customto afford a foamy solid
9. customupon evaporation in vacuo
10. customThis solid is crystallized from ethyl acetate/hexane