Butylamine → (E)-N-ethyl-6,6-dimethyl-2-hepten-4-ynylamine hydrochloride

To 15 ml of tetrahydrofuran were added 1.56 g (10 mmol) of (E)-N-(3-chloro-2-propenyl)ethylamine hydrochloride, 95.2 mg (0.5 mmol) of copper (I) iodide, 44.9 mg (0.2 mmol) of palladium acetate and 105 mg (0.4 mmol) of triphenylphosphine, and further, 2.97 ml (30 mmol) of n-butylamine and 1.47 ml (12 mmol) of tert-butylacetylene under ice cooling. The mixture was stirred for 18 hours at room temperature, and concentrated under reduced pressure. The residue was subjected to silica gel chromatography (n-hexane→n-hexane/ethyl acetate =9/1→3/7). The desired fractions were put together and concentrated under reduced pressure. The residue was dissolved in 3 ml of 17% hydrogen chloride isopropyl alcohol solution, and the solvent and excess hydrogen chloride were distilled off. The resulting crystals were suspended in 20 ml of a mixture of ethyl acetate and diisopropyl ether (1/3), cooled, filitered, washed with 5 ml of diisopropyl ether and dried to obtain 1.46 g (yield: 72%) of the above identified compound as off-white crystalline powder. Melting point, IR and NMR data of the isolated compound agreed with those of Example 2 compound.

1. concentrationconcentrated under reduced pressure
2. concentrationconcentrated under reduced pressure
3. dissolutionThe residue was dissolved in 3 ml of 17% hydrogen chloride isopropyl alcohol solution
4. distillationthe solvent and excess hydrogen chloride were distilled off
5. temperaturecooled
6. washwashed with 5 ml of diisopropyl ether
7. customdried
8. customto obtain 1.46 g (yield: 72%) of the

ORD record

ord-2104e3e467594531b67397ed71fe4a32

Source dataset

uspto-grants-1995_07

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05436354