Hydrochloric Acid → HCID 67021597, compound

HRID 1660980Notes

Reaction equation

HRID 1660980 reaction equation
C([O:3][C:4](=[O:22])[C:5]([C:7]1[CH:12]=[CH:11][C:10]([N:13]2[C:17]3=[N:18][CH:19]=[CH:20][CH:21]=[C:16]3[N:15]=[CH:14]2)=[CH:9][CH:8]=1)=[O:6])C.[Li+].[OH-].Cl>C1COCC1>[N:15]1[C:16]2[C:17](=[N:18][CH:19]=[CH:20][CH:21]=2)[N:13]([C:10]2[CH:9]=[CH:8][C:7]([C:5](=[O:6])[C:4]([OH:22])=[O:3])=[CH:12][CH:11]=2)[CH:14]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 67021415HCID 67021415, compound

Product 1

HCID 67021597HCID 67021597, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A mixture of (4-imidazo[4,5-b]pyridine-3-yl-phenyl)-oxo-acetic acid ethyl ester (123 mg, 0.417 mmol) and 1N LiOH (0.5 mL, 0.5 mmol) in THF (4 mL) is stirred at rt for 5 min. 1M HCl (500 μL) is then added and the resulting precipitate filtered off. (4-Imidazo[4,5-b]pyridine-3-yl-phenyl)-oxo-acetic acid is obtained as a grey solid. Title compound: ES-MS=268.05 [M+H]+; tR=0.8 min (System 2).

Workup

  1. filtrationthe resulting precipitate filtered off

Sources & evidence

ORD record
ord-737f793c87df41e6b1ec4cdb75034af0
Source dataset
uspto-grants-2011_10
Patent number
US08030311B2

Reaction notes

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