Hydrochloric Acid → Methyl 4-bromo-5-cyano-3-methylthiophene-2-carboxylate

HRID 166166Notes

Reaction equation

HRID 166166 reaction equation
[Br:4][c:5]1[c:6]([CH3:16])[c:7]([C:12](=[O:13])[O:14][CH3:15])[s:8][c:9]1[CH:10]=[O:11].[CH3:31][C:32]#[N:33].[CH3:40][CH2:41][O:42][C:43](=[O:44])[CH3:45].[ClH:1].[ClH:30].[F:17][C:18]([F:19])([F:20])[C:21]([O:22][C:23](=[O:24])[C:25]([F:26])([F:27])[F:28])=[O:29].[NH2:2][OH:3].[cH:34]1[cH:35][cH:36][n:37][cH:38][cH:39]1>>[N:2]#[C:10][c:9]1[c:5]([Br:4])[c:6]([CH3:16])[c:7]([C:12](=[O:13])[O:14][CH3:15])[s:8]1

Participants

8

Reactant 7

HCID 313Hydrochloric Acid2×HCID 787HydroxylamineHCID 1049PyridineHCID 6342AcetonitrileHCID 8857Ethyl AcetateHCID 9845Trifluoroacetic anhydrideHCID 71378553Methyl 4-bromo-5-formyl-3-methylthiophene-2-carboxylate

Product 1

HCID 66570703Methyl 4-bromo-5-cyano-3-methylthiophene-2-carboxylate

Sources & evidence

ORD record
ord-2108c07c23514e838692f84bb1a43671
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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