反应详情

To a solution of 66.63A (0.200 g, 0.689 mmol) in DMF (5 mL), was added NaH (0.0198 g, 0.827 mmol). The reaction was stirred at room temperature for 10 minutes. Ethyl iodide was then added and the reaction was stirred at room temperatures for 1 hour. The mixture was diluted with EtOAc, washed with water and brine, and dried over anhydrous Na2SO4. After removing solvent, the residue was purified by flash chromatography (silica gel, 1:1 EtOAc/hexane) and gave 67.23A in 79% yield. MS ESI (pos.) m/e: 336 (M+18)+.

1. stirringthe reaction was stirred at room temperatures for 1 hour
2. washwashed with water and brine
3. dry with materialdried over anhydrous Na2SO4
4. customAfter removing solvent
5. customthe residue was purified by flash chromatography (silica gel, 1:1 EtOAc/hexane)