Acetyl chloride → HCID 59239869, compound

HRID 1668391Notes

Reaction equation

HRID 1668391 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[S:16]C3C(=O)[N:13]([CH2:18][C:19]([C:21]4[CH:26]=[CH:25][C:24]([CH2:27][NH:28][CH3:29])=[CH:23][CH:22]=4)=[O:20])[CH:12]=[N:11][C:10]=3[CH:9]=2)=[CH:4][CH:3]=1.[C:30](Cl)(=[O:32])[CH3:31].C(N(CC)CC)C.[O:41]1CC[CH2:43][CH2:42]1>C(OCC)(=O)C.O>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[S:16][C:31]3[C:30](=[O:32])[N:13]([CH2:18][C:19]([C:21]4[CH:22]=[CH:23][C:24]([CH2:27][N:28]([CH3:29])[C:42](=[O:41])[CH3:43])=[CH:25][CH:26]=4)=[O:20])[CH:12]=[N:11][C:10]=3[CH:9]=2)=[CH:6][CH:7]=1

Participants

7

Reactant 4

HCID 6367Acetyl chlorideHCID 8028TetrahydrofuranHCID 8471TriethylamineHCID 59239832HCID 59239832, compound

Product 1

HCID 59239869HCID 59239869, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8857Ethyl AcetateSolvent

Procedure

A mixture of the compound (50 mg) obtained in Example 13, acetyl chloride (10 mg), triethylamine (18 mg) and tetrahydrofuran (1 ml) was stirred at room temperature for 30 min. The reaction mixture was diluted with ethyl acetate and water, and the precipitate was collected by filtration to give the title compound (39 mg) as a colorless powder.

Workup

  1. filtrationthe precipitate was collected by filtration

Sources & evidence

ORD record
ord-cba6c63c60734b379c52ff1b7e2ddfe1
Source dataset
uspto-grants-2011_08
Patent number
US07989445B2

Reaction notes

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