反应详情

温度

55 °C

9.9 g of potassium carbonate, 0.82 g of benzyltriethyl-ammonium chloride and 21 mL of 2-bromo-2-methylpropane were added to 14 mL of N,N-dimethylacetamide solution containing 0.93 g of 2-nitro-4-phenoxybenzoic acid at room temperature and stirred at 55° C. for 18 hours. After the reaction mixture was cooled to room temperature, water and ethyl acetate were added. The organic layer was separated and dried over anhydrous magnesium sulfate after washed with a saturated sodium hydrogen carbonate aqueous solution, 10% citric acid aqueous solution and a saturated sodium chloride aqueous solution sequentially, and the solvent was evaporated under reduced pressure to obtain 0.86 g of tert-butyl 2-nitro-4-phenoxybenzoate as white solid.

1. temperatureAfter the reaction mixture was cooled to room temperature
2. customThe organic layer was separated
3. dry with materialdried over anhydrous magnesium sulfate
4. washafter washed with a saturated sodium hydrogen carbonate aqueous solution, 10% citric acid aqueous solution
5. customa saturated sodium chloride aqueous solution sequentially, and the solvent was evaporated under reduced pressure