Benzyl Bromide → HCID 66995933, compound

HRID 1675619Notes

Reaction equation

HRID 1675619 reaction equation
[F:1][C:2]([F:12])([F:11])[C:3]1[CH:4]=[CH:5][C:6]([F:10])=[C:7]([OH:9])[CH:8]=1.[CH2:13](Br)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1.C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C>[F:10][C:6]1[CH:5]=[CH:4][C:3]([C:2]([F:1])([F:11])[F:12])=[CH:8][C:7]=1[O:9][CH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

Participants

5

Reactant 3

HCID 7498Benzyl BromideHCID 11430Potassium CarbonateHCID 5188882-Fluoro-5-(trifluoromethyl)phenol

Product 1

HCID 66995933HCID 66995933, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A mixture of 5-(trifluoromethyl)-2-fluorophenol (2.0 g), benzyl bromide (1.45 ml) and potassium carbonate (1.65 g) in dry DMF (20 ml) was stirred at RT overnight. The mixture was quenched with water and the solid filtered and dried, yield 2.20 g.

Workup

  1. customThe mixture was quenched with water
  2. filtrationthe solid filtered
  3. customdried

Sources & evidence

ORD record
ord-540823e120f74b9e87c2e5bca072348f
Source dataset
uspto-grants-2011_08
Patent number
US08003703B2

Reaction notes

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