Ethylparaben → HCID 19069386, compound

HRID 1678871Notes

Reaction equation

HRID 1678871 reaction equation
Cl[C:2]1[S:3][CH:4]=[CH:5][N:6]=1.[OH:7][C:8]1[CH:18]=[CH:17][C:11]([C:12]([O:14][CH2:15][CH3:16])=[O:13])=[CH:10][CH:9]=1.C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[S:3]1[CH:4]=[CH:5][N:6]=[C:2]1[O:7][C:8]1[CH:9]=[CH:10][C:11]([C:12]([O:14][CH2:15][CH3:16])=[O:13])=[CH:17][CH:18]=1

Participants

5

Reactant 3

HCID 8434EthylparabenHCID 11430Potassium CarbonateHCID 764292-Chlorothiazole

Product 1

HCID 19069386HCID 19069386, compoundYield 27.8%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A mixture of 2-chlorothiazole (2.0 g), ethyl 4-hydroxybenzoate (2.8 g), potassium carbonate powder (3.5 g) and dimethylformamide (30 ml) is stirred at 135°-140° C for 6 hours. The reaction mixture is treated in the same manner as in Example 1. From the eluate of 30% ether-benzene, ethyl 4-(2-thiazolyloxy)benzoate (1.16 g) is obtained. IR νmaxCCl 4 1730, 1280 cm-1.

Workup

  1. additionThe reaction mixture is treated in the same manner as in Example 1

Sources & evidence

ORD record
ord-eff65ec915e3461ca31928c7124aae33
Source dataset
uspto-grants-1978_03
Patent number
US04077968

Reaction notes

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