Hydrochloric Acid → HCID 70550317, compound

HRID 1680185Notes

Reaction equation

HRID 1680185 reaction equation
[C:1]12([NH:12][C:13](=[O:17])[CH:14]([Cl:16])[CH3:15])[CH2:10][CH:6]([CH2:7][CH2:8][CH2:9]1)[CH:5]1[CH2:11][CH:2]2[CH2:3][CH2:4]1.C1(=O)[NH:22]C(=O)C2=CC=CC=C12.O.NN.Cl>>[ClH:16].[C:1]12([NH:12][C:13](=[O:17])[CH:14]([NH2:22])[CH3:15])[CH2:10][CH:6]([CH2:7][CH2:8][CH2:9]1)[CH:5]1[CH2:11][CH:2]2[CH2:3][CH2:4]1

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 6809PhthalimideHCID 24654Hydrazine hydrate (1:1)HCID 57141884HCID 57141884, compound

Product 1

HCID 70550317HCID 70550317, compoundYield 32%

Procedure

Under the same conditions as described in sections (D) and (E) of Example 8, N-(1-tricyclo[4.3.1.12,5 ]undecyl)-2-chloropropionamide was converted to the phthalimide derivative, the derivative was converted to an amine by 80% hydrazine hydrate and the amine was neutralized by hydrogen chloride gas to obtain viscous N-(1-tricyclo[4.3.1.12,5 ]undecyl)-2-aminopropionamide hydrochloride in a yield of 32%.

Sources & evidence

ORD record
ord-c5433e56c36a446a9e10c09e901f9027
Source dataset
uspto-grants-1981_06
Patent number
US04272536

Reaction notes

Loading…