Hydrochloric Acid → HCID 15067717, compound

HRID 1681309Notes

Reaction equation

HRID 1681309 reaction equation
[Na].[C:2]1([S:8]([NH2:11])(=[O:10])=[O:9])[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:12][N:13]1[C:21]2[C:16](=[N:17][C:18]([Cl:23])=[N:19][C:20]=2[Cl:22])[N:15]=[C:14]1Cl.Cl>CN(C=O)C>[Cl:23][C:18]1[N:17]=[C:16]2[C:21]([N:13]([CH3:12])[C:14]([NH:11][S:8]([C:2]3[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=3)(=[O:10])=[O:9])=[N:15]2)=[C:20]([Cl:22])[N:19]=1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 7370BenzenesulfonamideHCID 2508972,6,8-trichloro-7-methylpurineHCID 5360545Sodium

Product 1

HCID 15067717HCID 15067717, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

10.8 g (50.0 mmol) of the sodium salt of benzenesulfonamide was suspended in 100 ml of DMF; at 60° C., 11.9 g (50.0 mmol) of 7-methyl-2,6,8-trichloropurine was added. After 8 hours at 80° C. and cooling to room temperature, H2O/ice was added, the mixture was acidified with 10% strength hydrochloric acid and the precipitate was suction filtered and dried.

Workup

  1. filtrationfiltered
  2. customdried

Sources & evidence

ORD record
ord-3533c7d6fd4c466898e4b4a747be5324
Source dataset
uspto-grants-1992_12
Patent number
US05171353

Reaction notes

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