Hydrochloric Acid → HCID 70148563, compound

HRID 1681890Notes

Reaction equation

HRID 1681890 reaction equation
[NH2:1][C:2]1[CH:7]=[C:6]([C:8]([OH:10])=[O:9])[CH:5]=[CH:4][N:3]=1.[ClH:11]>CO.O=[Pt]=O>[ClH:11].[NH2:1][C:2]1[CH2:7][CH:6]([C:8]([OH:10])=[O:9])[CH2:5][CH2:4][N:3]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 2783962-Aminopyridine-4-carboxylic acid

Product 1

HCID 70148563HCID 70148563, compoundYield 88%

Reagents, catalysts & solvents 2

HCID 345198Adams' catalystCatalystHCID 887MethanolSolvent

Procedure

2-Aminopyridine-4-carboxylic acid (Farmaco. Ed. Sci. 1958, 13, 485; 1.38 g, 10 mmol) was dissolved in 90% methanol (210 ml) and conc. HCl(4.9 ml, 60 mmol) was added. The solution was hydrogenated over PtO2 (200 mg) in a Parr shaker apparatus at room temperature and 29 psig for 2 hours. Filtration and evaporation gave 1.57 g (88%) crude white crystals identified as the product by 300 MHz nmr and ir 1728 cm-1.

Workup

  1. filtrationFiltration and evaporation

Sources & evidence

ORD record
ord-809fc5738a124b0597541af8374d45fd
Source dataset
uspto-grants-1992_12
Patent number
US05175166

Reaction notes

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