Triethylamine → 1-Butyl-6-chloro-4-methyl-3-oxo-1,3-dihydropyrazolo[3,4-b]pyridine-2-carboxylic acid hexylamide

HRID 1685230Notes

Reaction equation

HRID 1685230 reaction equation
[CH2:1]([NH:7][C:8]([N:10]1[C:18](=[O:19])[C:17]2[C:12](=[N:13][C:14]([Cl:21])=[CH:15][C:16]=2[CH3:20])[NH:11]1)=[O:9])[CH2:2][CH2:3][CH2:4][CH2:5][CH3:6].I[CH2:23][CH2:24][CH2:25][CH3:26].C(N(CC)CC)C>CN(C=O)C>[CH2:1]([NH:7][C:8]([N:10]1[C:18](=[O:19])[C:17]2[C:12](=[N:13][C:14]([Cl:21])=[CH:15][C:16]=2[CH3:20])[N:11]1[CH2:23][CH2:24][CH2:25][CH3:26])=[O:9])[CH2:2][CH2:3][CH2:4][CH2:5][CH3:6]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 10962Butyl iodideHCID 86628147HCID 86628147, compound

Product 1

HCID 167476711-Butyl-6-chloro-4-methyl-3-oxo-1,3-dihydropyrazolo[3,4-b]pyridine-2-carboxylic acid hexylamide

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

In analogy to example 2, 100 mg (0.32 mmol) of 6-chloro-4-methyl-3-oxo-1,3-dihydropyrazolo[3,4-b]pyridine-2-carboxylic acid hexylamide were reacted with 59.2 mg (0.32 mmol) of 1-iodobutane in DMF with triethylamine at RT. Yield: 23 mg (19%), M+H+: 367.27.

Sources & evidence

ORD record
ord-982511f9a9704f4bb984d0027e8d37bc
Source dataset
uspto-grants-2012_04
Patent number
US08148395B2

Reaction notes

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