Phthalimide → HCID 67264543, compound

HRID 1686135Notes

Reaction equation

HRID 1686135 reaction equation
CS(O[CH:6]([CH3:15])[CH2:7][CH2:8][CH:9]1[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]1)(=O)=O.[C:16]1(=[O:26])[NH:20][C:19](=[O:21])[C:18]2=[CH:22][CH:23]=[CH:24][CH:25]=[C:17]12.C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C>[CH:9]1([CH2:8][CH2:7][CH:6]([N:20]2[C:16](=[O:26])[C:17]3[C:18](=[CH:22][CH:23]=[CH:24][CH:25]=3)[C:19]2=[O:21])[CH3:15])[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]1

Participants

5

Reactant 3

HCID 6809PhthalimideHCID 11430Potassium CarbonateHCID 86643789HCID 86643789, compound

Product 1

HCID 67264543HCID 67264543, compoundYield 58.1%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent2×

Conditions

Temperature
80 °C

Procedure

A solution of 7.00 g 3-cyclohexyl-1-methylpropyl methanesulfonate in 20 mL DMF was added to a solution of 5.14 g phthalimide and 7.43 g of potassium carbonate in 50 mL DMF at room temperature. The reaction mixture was stirred at 80° C. over night. Aqueous work-up followed by silica gel filtration yielded 4.95 g (58%) of a colourless oil.

Workup

  1. filtrationAqueous work-up followed by silica gel filtration

Sources & evidence

ORD record
ord-9b15a064074541ae9b5f2ac89c013c7c
Source dataset
uspto-grants-2012_04
Patent number
US08148538B2

Reaction notes

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