Water → HCID 178448902, Verbindung

HRID 1688469Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1688469
[CH3:1][O:2][CH2:3][C:4]1[NH:5][C:6]([NH2:9])=[N:7][N:8]=1.[CH3:10][C:11](=O)[CH2:12][CH3:13].C([BH3-])#N.[Na+].O>C(O)(=O)C>[CH3:1][O:2][CH2:3][C:4]1[NH:5][C:6]([NH:9][CH:11]([CH3:10])[CH2:12][CH3:13])=[N:7][N:8]=1

Komponenten

6

Edukt 4

HCID 962WaterHCID 6569Methyl Ethyl KetoneHCID 5003444Sodium cyanoborohydrideHCID 178494711HCID 178494711, Verbindung

Produkt 1

HCID 178448902HCID 178448902, VerbindungAusbeute 45 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

To a solution (5 mL) of 5-(methoxymethyl)-4H-1,2,4-triazol-3-amine (0.3 g) and butan-2-one (0.25 mL) in acetic acid was added sodium cyanoborohydride (0.6 g), and the mixture was stirred at room temperature for 16 hr. Water was added to the reaction mixture, and the solvent was evaporated under reduced pressure. The obtained residue was poured into saturated aqueous sodium hydrogen carbonate, and the mixture was extracted with a mixed solvent of ethyl acetate and isopropyl alcohol (3:1). The obtained extract was dried over anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure to give the title compound as a colorless solid (0.2 g, 45%).

Aufarbeitung

  1. customthe solvent was evaporated under reduced pressure
  2. additionThe obtained residue was poured into saturated aqueous sodium hydrogen carbonate
  3. extractionthe mixture was extracted with a mixed solvent of ethyl acetate and isopropyl alcohol (3:1)
  4. extractionThe obtained extract
  5. dry with materialwas dried over anhydrous sodium sulfate
  6. customthe solvent was evaporated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-c1c32ecac79a4d248660a3072cb9933d
Quelldatensatz
uspto-grants-2012_04
Patentnummer
US08148383B2

Notizen zur Reaktion

Wird geladen…