Dimethylformamide → 5-Bromo-3-((trimethylsilyl)ethynyl)pyrazin-2-amine

HRID 169269Notes

Reaction equation

HRID 169269 reaction equation
[Br:1][c:2]1[c:3]([NH2:9])[n:4][cH:5][c:6]([Br:8])[n:7]1.[CH3:10][CH2:11][N:12]([CH2:13][CH3:14])[CH2:15][CH3:16].[CH3:17][Si:18]([CH3:19])([CH3:20])[C:21]#[CH:22].[Cu:28][I:29].[O:23]=[CH:24][N:25]([CH3:26])[CH3:27]>>[c:2]1([C:22]#[C:21][Si:18]([CH3:17])([CH3:19])[CH3:20])[c:3]([NH2:9])[n:4][cH:5][c:6]([Br:8])[n:7]1

Participants

6

Reactant 5

HCID 6228DimethylformamideHCID 8471TriethylamineHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 66111TrimethylsilylacetyleneHCID 6200042-Amino-3,5-dibromopyrazine

Product 1

HCID 533931895-Bromo-3-((trimethylsilyl)ethynyl)pyrazin-2-amine

Sources & evidence

ORD record
ord-57f5ff16582645bdbe8130d94c2c7c9a
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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