Methylamine → N-Methylbenzylamine

HRID 1698299Notes

Reaction equation

HRID 1698299 reaction equation
ClCC=[CH:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1.[CH3:11][NH2:12]>>[CH3:11][NH:12][CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1

Participants

3

Reactant 2

HCID 6329Methylamine2×HCID 94242Benzene, (3-chloro-1-propenyl)-

Product 1

HCID 7669N-Methylbenzylamine

Procedure

The N-methylaminomethyl polystyrene resin is prepared as follows: To liquid methylamine, kept below −20° C., chloromethylstyrene copolymer (Merrifield resin) is added (˜1 g of resin per 10 ml of methylamine). The suspension is shaken in a pressure bottle at RT for 14 h. The resin is filtered off and washed with DMA (2×), H2O (2×), DMA (1×), CH3OH (2×), CH2Cl2 (3×), CH3OH (2×) and dried under high vacuum.

Workup

  1. customkept below −20° C.
  2. filtrationThe resin is filtered off
  3. washwashed with DMA (2×), H2O (2×), DMA (1×), CH3OH (2×), CH2Cl2 (3×), CH3OH (2×)
  4. customdried under high vacuum

Sources & evidence

ORD record
ord-554ae9f5b41d4bd29cf005d7a9cb373f
Source dataset
uspto-grants-2012_04
Patent number
US08163773B2

Reaction notes

Loading…