Ethyl Bromide → HCID 178420660, compound

HRID 1699151Notes

Reaction equation

HRID 1699151 reaction equation
C([Br:3])C.[Mg:4].C12(C([O:17][CH2:18][CH2:19][CH2:20][CH3:21])=O)CC3CC(CC(C3)C1)C2>O1CCCC1>[CH2:20]([Mg:4][Br:3])[CH3:21].[O:17]1[CH2:18][CH2:19][CH2:20][CH2:21]1

Participants

5

Reactant 3

HCID 6332Ethyl BromideHCID 5462224MagnesiumHCID 12670037HCID 12670037, compound

Product 1

HCID 178420660HCID 178420660, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Initially, a 13% by weight ethylmagnesium bromide-tetrahydrofuran solution was prepared from ethyl bromide and metallic magnesium, and 61.51 g (0.060 mol) of the solution was placed in a flask. To this solution was added dropwise a solution of 4.76 g (0.02 mol) of n-butyl 1-adamantanecarboxylate in 7.21 g of tetrahydrofuran while maintaining the inner temperature not exceeding 35° C., followed by stirring at room temperature for 1 hour.

Workup

  1. customwas placed in a flask
  2. temperaturewhile maintaining the inner temperature not
  3. customexceeding 35° C.

Sources & evidence

ORD record
ord-2325e7491fb8437fa9ef58b8e057a9b0
Source dataset
uspto-grants-2002_02
Patent number
US06344590B1

Reaction notes

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