Hydrochloric Acid → 1956-39-4

HRID 1703432Notes

Reaction equation

HRID 1703432 reaction equation
[CH3:1][C:2]([C:4]1[CH:9]=[CH:8][C:7]([Cl:10])=[CH:6][CH:5]=1)=O.Cl.[OH:12][NH2:13].[OH-].[Na+].Cl.ON>C(O)C.O>[CH3:1]/[C:2](/[C:4]1[CH:9]=[CH:8][C:7]([Cl:10])=[CH:6][CH:5]=1)=[N:13]/[OH:12]

Participants

8

Reactant 5

HCID 313Hydrochloric AcidHCID 787HydroxylamineHCID 7467P-ChloroacetophenoneHCID 14798Sodium HydroxideHCID 443297Hydroxyamine hydrochloride

Product 1

HCID 54625571956-39-4Yield 92%

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent3×

Procedure

15.5 grams (approximately 0.1 mole) of 4-chloroacetophenone were dissolved in 50 cc of ethyl alcohol in a 250 cc beaker. Thereafter, a solution consisting of 15 grams (0.214 mole) of hydroxyl amine hydrochloride dissolved in 30 cc of water were added to the beaker. Then, another solution consisting of 10 grams (0.25 mole) of sodium hydroxide dissolved in 30 cc of water were added to the beaker and the resultant solution was heated for 10 minutes on a hot plate. The reaction mixture was cooled to room temperature and poured into another beaker containing about 250 cc of cold water. The resultant mixture was acidified to a pH of 3 to 5 with strong hydrochloric acid to dissolve any unreacted hydroxyl amine. The white solid product was removed by filtration and after washing and drying, 15.6 grams of crude 4-chloroacetophenone oxime product were obtained.

Workup

  1. additionwere added to the beaker
  2. additionwere added to the beaker
  3. additionpoured into another beaker
  4. customThe white solid product was removed by filtration
  5. washafter washing
  6. customdrying

Sources & evidence

ORD record
ord-ee1b20dcecf9413bbd2f99277a5bc44d
Source dataset
uspto-grants-1978_11
Patent number
US04124227

Reaction notes

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