Tetrahydrofuran → 1,1-Bis(3-fluorophenyl)-N-[2-[cyclopropyl[(2-nitrophenyl)sulfonyl]amino]ethyl]-tetrahydro-3-oxo-3H-oxazolo[3,4-a]pyrazine-7(1H)-carboxamide

HRID 170413Notes

Reaction equation

HRID 170413 reaction equation
[CH3:71][CH2:72][O:73][C:74](=[O:75])[CH3:76].[CH:20]([N:21]([CH:22]([CH3:23])[CH3:24])[CH2:25][CH3:26])([CH3:27])[CH3:28].[Cl:29][C:30](=[O:31])[O:32][c:33]1[cH:34][cH:35][c:36]([N+:37]([O-:38])=[O:39])[cH:40][cH:41]1.[F:42][c:43]1[cH:44][c:45]([C:49]2([c:59]3[cH:60][c:61]([F:65])[cH:62][cH:63][cH:64]3)[O:50][C:51](=[O:58])[N:52]3[CH:53]2[CH2:54][NH:55][CH2:56][CH2:57]3)[cH:46][cH:47][cH:48]1.[NH2:1][CH2:2][CH2:3][N:4]([S:5](=[O:6])(=[O:7])[c:8]1[c:9]([N+:14](=[O:15])[O-:16])[cH:10][cH:11][cH:12][cH:13]1)[CH:17]1[CH2:18][CH2:19]1.[O:66]1[CH2:67][CH2:68][CH2:69][CH2:70]1>>[NH:1]([CH2:2][CH2:3][N:4]([S:5](=[O:6])(=[O:7])[c:8]1[c:9]([N+:14](=[O:15])[O-:16])[cH:10][cH:11][cH:12][cH:13]1)[CH:17]1[CH2:18][CH2:19]1)[C:30](=[O:31])[N:55]1[CH2:54][CH:53]2[C:49]([c:45]3[cH:44][c:43]([F:42])[cH:48][cH:47][cH:46]3)([c:59]3[cH:60][c:61]([F:65])[cH:62][cH:63][cH:64]3)[O:50][C:51](=[O:58])[N:52]2[CH2:57][CH2:56]1

Participants

7

Reactant 6

HCID 8028TetrahydrofuranHCID 8857Ethyl AcetateHCID 81531DiisopropylethylamineHCID 821294-Nitrophenyl chloroformateHCID 23121868N-(2-aminoethyl)-N-cyclopropyl-2-nitrobenzenesulfonamideHCID 231220271,1-Bis(3-fluorophenyl)-hexahydro-3H-oxazolo[3,4-a]pyrazin-3-one

Product 1

HCID 231219611,1-Bis(3-fluorophenyl)-N-[2-[cyclopropyl[(2-nitrophenyl)sulfonyl]amino]ethyl]-tetrahydro-3-oxo-3H-oxazolo[3,4-a]pyrazine-7(1H)-carboxamide

Sources & evidence

ORD record
ord-e434ea5a866f4512bfd609c9d1db7eca
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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