Hydrochloric Acid → HCID 15696556, compound

HRID 1709186Notes

Reaction equation

HRID 1709186 reaction equation
[C:1]1(=[O:7])[NH:5][C:4](=[O:6])[CH2:3][CH2:2]1.[H-].[B].[Na].Cl.[OH-].[K+].[CH:14](O)([CH3:16])[CH3:15]>>[CH:14]([O:6][CH:4]1[NH:5][C:1](=[O:7])[CH2:2][CH2:3]1)([CH3:16])[CH3:15]

Participants

8

Reactant 7

HCID 313Hydrochloric AcidHCID 3776Isopropanol3×HCID 11439SuccinimideHCID 14797Potassium HydroxideHCID 166653HydrideHCID 5360545SodiumHCID 5462311Boron

Product 1

HCID 15696556HCID 15696556, compound

Conditions

Temperature
-10 °C

Procedure

28.4 g of succinimide in 1200 cm3 of isopropanol is cooled to -10° C., 32.8 g of hydride of boron and sodium is added, and after agitating for 4 hours at 0°/-10° C., there is added a 2N solution of hydrochloric acid in isopropanol, adjusting the pH to 2-3. This is maintained for 2 hours at 0° C., then neutralised with a solution of potassium hydroxide in isopropanol. The solvent is evaporated under reduced pressure, the residue is taken up with chloroform, concentrated to dryness under reduced pressure, and 20.5 g of the expected product is obtained. m.p. 68°-71° C.

Workup

  1. temperatureThis is maintained for 2 hours at 0° C.
  2. customThe solvent is evaporated under reduced pressure
  3. concentrationconcentrated to dryness under reduced pressure

Sources & evidence

ORD record
ord-bc0f91fe2d9d4ed391ebe67dbf497a40
Source dataset
uspto-grants-1990_08
Patent number
US04948804

Reaction notes

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