Hydrochloric Acid → HCID 178453906, compound

HRID 1714393Notes

Reaction equation

HRID 1714393 reaction equation
[F:1][C:2]1[CH:3]=[CH:4][C:5]([O:10][CH:11]2[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]2)=[C:6]([CH:9]=1)[C:7]#[N:8].Cl.[C:18]([O:22][C:23](=[O:34])[NH:24][C@H:25]1[CH2:30][CH2:29][C@H:28]([CH2:31][CH:32]=O)[CH2:27][CH2:26]1)([CH3:21])([CH3:20])[CH3:19].C(O[BH-](OC(=O)C)OC(=O)C)(=O)C.[Na+]>ClCCCl>[C:18]([O:22][C:23](=[O:34])[NH:24][C@H:25]1[CH2:26][CH2:27][C@H:28]([CH2:31][CH2:32][N:14]2[CH2:15][CH2:16][CH:11]([O:10][C:5]3[CH:4]=[CH:3][C:2]([F:1])=[CH:9][C:6]=3[C:7]#[N:8])[CH2:12][CH2:13]2)[CH2:29][CH2:30]1)([CH3:21])([CH3:20])[CH3:19]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 5049666Sodium triacetoxyborohydrideHCID 63674670HCID 63674670, compoundHCID 178453924HCID 178453924, compound

Product 1

HCID 178453906HCID 178453906, compound

Reagents, catalysts & solvents 1

HCID 111,2-DichloroethaneSolvent

Procedure

The title compound was prepared analogously to example 1 (1.3) starting from 5-Fluoro-2-(piperidin-4-yloxy)-benzonitrile; hydrochloride and Trans-[4-(2-Oxo-ethyl)-cyclohexyl]-carbamic acid tert-butyl ester with sodium triacetoxyborohydride in 1,2-dichloroetane. MS (m/e): 446.3 (M+H+)

Sources & evidence

ORD record
ord-6044bf1e29ca4c1aa5f00bb892a725e1
Source dataset
uspto-grants-2010_09
Patent number
US07795437B2

Reaction notes

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