Potassium Carbonate → HCID 178456761, compound

HRID 1722709Notes

Reaction equation

HRID 1722709 reaction equation
F[C:2]1[CH:15]=[CH:14][C:5]([C:6]([NH:8][C:9]2[NH:13][N:12]=[N:11][N:10]=2)=[O:7])=[CH:4][CH:3]=1.[CH2:16]([NH2:19])[C:17]#[CH:18].[F-].[K+].C(=O)([O-])[O-].[K+].[K+]>CS(C)=O.O>[CH2:16]([NH:19][C:2]1[CH:15]=[CH:14][C:5]([C:6]([NH:8][C:9]2[NH:13][N:12]=[N:11][N:10]=2)=[O:7])=[CH:4][CH:3]=1)[C:17]#[CH:18]

Participants

7

Reactant 4

HCID 11430Potassium CarbonateHCID 239041PropargylamineHCID 522689Potassium FluorideHCID 178522677HCID 178522677, compound

Product 1

HCID 178456761HCID 178456761, compound

Reagents, catalysts & solvents 2

HCID 679Dimethyl SulfoxideSolventHCID 962WaterSolvent

Procedure

A mixture of 20 g (0.097 mol) of 4-fluoro-N-1H-tetrazol-5-ylbenzamide, 12.8 ml (0.193 mol) of propargylamine, 5.6 g of anhydrous potassium fluoride, and 13 g of potassium carbonate, in 320 ml of dimethylsulfoxide is heated at 50°-70° C. for six to twenty hours. The reaction is poured into water and the precipitate is collected, washed with water, and dried in vacuo to give the title compound.

Workup

  1. customthe precipitate is collected
  2. washwashed with water
  3. customdried in vacuo

Sources & evidence

ORD record
ord-4257f44f38554c3e9c8c4201b1edf2f5
Source dataset
uspto-grants-1989_08
Patent number
US04857530

Reaction notes

Loading…