Chloride → Hydrochloric Acid

HRID 1723627Notes

Reaction equation

HRID 1723627 reaction equation
[CH2:1]([O:8][C:9](=[O:24])[NH:10][CH:11]1[CH2:16][CH2:15][CH:14]([N:17]([CH3:23])[C:18](=[N:21][CH3:22])SC)[CH2:13][CH2:12]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.I.CCO.O.[NH2:30][NH2:31].[Cl-:32]>>[CH2:1]([O:8][C:9](=[O:24])[NH:10][CH:11]1[CH2:16][CH2:15][CH:14]([N:17]([CH3:23])[C:18]([NH:30][NH2:31])=[N:21][CH3:22])[CH2:13][CH2:12]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:32]

Participants

7

Reactant 5

HCID 312ChlorideHCID 702EthanolHCID 24654Hydrazine hydrate (1:1)HCID 24841Hydrogen iodideHCID 68981797HCID 68981797, compound

Product 2

HCID 313Hydrochloric AcidHCID 68980335HCID 68980335, compound

Procedure

0.84 g of [4-(1,2,3-trimethyl-isothioureido)-cyclohexyl]carbamic acid benzylester in the form of a hydroiodide are stirred with 10 ml of of a strong basic ion exchanger in chloride form. A suspension obtained is filtered and the filtrate obtained is lyophilized. The lyophilisate is treated with 15 ml of EtOH and with 0.08 ml of hydrazine monohydrate. The mixture obtained is refluxed for 2.5 hours and from the mixture obtained solvent is evaporated. [4-(3-Amino-1,2-dimethyl-guanidino)-cyclohexyl]-carbamic acid benzylester in the form of a hydrochloride is obtained.

Workup

  1. customA suspension obtained
  2. filtrationis filtered
  3. customthe filtrate obtained
  4. customThe mixture obtained
  5. temperatureis refluxed for 2.5 hours and from the mixture
  6. customobtained solvent
  7. customis evaporated

Sources & evidence

ORD record
ord-9b19962bafd74275a9dbc508e2813d53
Source dataset
uspto-grants-2009_02
Patent number
US07485632B2

Reaction notes

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