Hydrogen Bromide → HCID 57420547, compound

HRID 1723859Notes

Reaction equation

HRID 1723859 reaction equation
[BrH:1].[F:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[N:9]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[C:11]([O:18][CH:19]2[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]2)=[N:10]1.N#N.CC(OC)(C)C>CO>[BrH:1].[F:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[N:9]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[C:11]([O:18][CH:19]2[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]2)=[N:10]1

Participants

6

Reactant 4

HCID 260Hydrogen BromideHCID 947NitrogenHCID 15413tert-Butyl methyl etherHCID 11510935HCID 11510935, compound

Product 1

HCID 57420547HCID 57420547, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

4.840 mg of concentrated hydrobromic acid was added to 0.89 ml of a solution of 1-(2-fluorophenyl)-3-(piperidin-4-yloxy)-1H-indazole in MeOH (concentration=10.3 mg/ml). The solution was placed under a stream of N2 gas until no solvent remained. Approximately 0.5 ml of MTBE was added and the sample was left open and stirred overnight. A white solid remained upon recovery.

Workup

  1. waitthe sample was left open

Sources & evidence

ORD record
ord-10276e7162f24b6aa1b270477fd6737f
Source dataset
uspto-grants-2009_02
Patent number
US07485636B2

Reaction notes

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