Phenylacetic Acid → HCID 26338416, compound

HRID 1734218Notes

Reaction equation

HRID 1734218 reaction equation
P(Cl)(Cl)(Cl)=O.[C:6]1([CH2:12][C:13]([OH:15])=O)[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1.C(=O)([O-])[O-].[K+].[K+].[CH3:22][N:23]([CH3:26])[CH:24]=O>>[CH3:22][N:23]([CH3:26])[CH:24]=[C:12]([C:6]1[CH:7]=[CH:8][CH:9]=[CH:10][CH:11]=1)[CH:13]=[O:15]

Participants

5

Reactant 4

HCID 999Phenylacetic AcidHCID 6228Dimethylformamide2×HCID 11430Potassium CarbonateHCID 24813Phosphorus oxychloride

Product 1

HCID 26338416HCID 26338416, compound

Conditions

Temperature
70 °C

Procedure

Phosphorus oxychloride, 690 grams (4.5 moles), is warmed to about 30° C., and 478 mL of N,N-dimethylformamide is added dropwise during a two hour period. Upon completion of addition, a solution of 202 grams (1.5 moles) of phenylacetic acid in 158 mL of N,N-dimethylformamide is added dropwise during a one hour period. Upon completion of the addition, the reaction mixture is slowly warmed to about 70°-75° C. where it is stirred for about 16 hours. After this time the reaction mixture is poured into five kilograms of ice. Two kilograms of potassium carbonate are added, and the mixture is stirred until the ice melted. The mixture is separated into two five liter reaction vessels, and 500 mL of toluene is added to each of the vessels. The stirred mixtures are then warmed to about 70° C. where they stirred for about 16 hours. After this time, the mixtures in each vessel are extracted with three 500 mL portions of toluene. The combined extracts are then washed with two one liter portions of water and one one liter portion of an aqueous solution saturated with sodium chloride. The organic layer is dried with potassium carbonate and filtered. The filtrate is concentrated under reduced pressure, yielding 94.9 grams of crude product. The crude product is distilled under vacuum, yielding 78.3 grams of 3-dimethylamino-2-phenylpropenaldehyde, bp 154°-160° C./1 mm Hg. The NMR spectrum is consistent with the proposed structure.

Workup

  1. additionUpon completion of addition
  2. additionUpon completion of the addition
  3. temperaturethe reaction mixture is slowly warmed to about 70°-75° C. where it
  4. customThe mixture is separated into two five liter reaction vessels, and 500 mL of toluene
  5. additionis added to each of the vessels
  6. stirringstirred for about 16 hours
  7. extractionAfter this time, the mixtures in each vessel are extracted with three 500 mL portions of toluene
  8. washThe combined extracts are then washed with two one liter portions of water and one one liter portion of an aqueous solution saturated with sodium chloride
  9. dry with materialThe organic layer is dried with potassium carbonate
  10. filtrationfiltered
  11. concentrationThe filtrate is concentrated under reduced pressure
  12. customyielding 94.9 grams of crude product
  13. distillationThe crude product is distilled under vacuum

Sources & evidence

ORD record
ord-574be4a252de4f0083be447e3df99ace
Source dataset
uspto-grants-1996_07
Patent number
US05532370

Reaction notes

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