Water → HCID 19068979, compound

HRID 1735122Notes

Reaction equation

HRID 1735122 reaction equation
[H-].[Na+].[C:3]([C:6]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[NH:8][C:7]=1[Cl:15])(=[O:5])[CH3:4].[CH2:16](Br)[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1.O>C1COCC1>[CH2:16]([N:8]1[C:9]2[C:14](=[CH:13][CH:12]=[CH:11][CH:10]=2)[C:6]([C:3](=[O:5])[CH3:4])=[C:7]1[Cl:15])[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1

Participants

6

Reactant 4

HCID 962WaterHCID 7498Benzyl BromideHCID 24758Sodium hydrideHCID 109323071-(2-Chloro-1H-indol-3-yl)ethan-1-one

Product 1

HCID 19068979HCID 19068979, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a slurry of 400 mg of NaH in 20 ml THF was added 1 g of (75), and then 770 μl of benzyl bromide. The reaction was left with stirring for 3 days. Water was added, and the product extracted with diethylether, dried, and the solvent evaporated off to give 1.52 g of a redbrown powder, which was used without further purification.

Workup

  1. waitThe reaction was left
  2. extractionthe product extracted with diethylether
  3. customdried
  4. customthe solvent evaporated off

Sources & evidence

ORD record
ord-0ca8ca27525c4a3a86175dff9f4f6143
Source dataset
uspto-grants-1996_07
Patent number
US05536721

Reaction notes

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