1,2-Dichloroethane → 5-bromo-2-(4-fluorophenyl)-N-methyl-1H-indole-3-carboxamide

HRID 174848Notes

Reaction equation

HRID 174848 reaction equation
[B:25]([Br:26])([Br:27])[Br:28].[Br:1][c:2]1[cH:3][c:4]2[c:5]([C:18]([O:20][CH2:19][CH3:21])=[O:22])[c:6](-[c:11]3[cH:12][cH:13][c:14]([F:17])[cH:15][cH:16]3)[nH:7][c:8]2[cH:9][cH:10]1.[CH2:34]1[O:35][CH2:36][CH2:37][CH2:38]1.[CH3:32][NH2:33].[Cl:29][CH2:30][Cl:31].[Cl:39][CH2:40][CH2:41][Cl:42].[N:23]#[N:24]>>[Br:1][c:2]1[cH:3][c:4]2[c:5]([C:18](=[O:20])[NH:33][CH3:32])[c:6](-[c:11]3[cH:12][cH:13][c:14]([F:17])[cH:15][cH:16]3)[nH:7][c:8]2[cH:9][cH:10]1

Participants

8

Reactant 7

HCID 111,2-DichloroethaneHCID 947NitrogenHCID 6329MethylamineHCID 6344DichloromethaneHCID 8028TetrahydrofuranHCID 25134Boron tribromideHCID 59233823ethyl 5-bromo-2-(4-fluorophenyl)-1H-indole-3-carboxylate

Product 1

HCID 592338075-bromo-2-(4-fluorophenyl)-N-methyl-1H-indole-3-carboxamide

Sources & evidence

ORD record
ord-48763eb1e85040089cb825c9c9a90515
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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