Chloride → 1-[5-({[tert-butyl(diphenyl)silyl]oxy}methyl)-1,3,4-thiadiazol-2-yl]-5-[4-(cyclopropylsulfonyl)phenyl]-6-(tetrahydro-2H-pyran-4-yl)hexane-1,4-dione

HRID 174891Notes

Reaction equation

HRID 174891 reaction equation
[C:33]([CH3:34])([CH3:35])([CH3:36])[Si:37]([O:38][CH2:39][c:40]1[n:41][n:42][c:43]([CH:45]=[O:46])[s:44]1)([c:47]1[cH:48][cH:49][cH:50][cH:51][cH:52]1)[c:53]1[cH:54][cH:55][cH:56][cH:57][cH:58]1.[CH2:60]([n+:61]1[c:62]([CH3:63])[c:64]([CH2:65][CH2:66][OH:67])[s:68][cH:69]1)[c:70]1[cH:71][cH:72][cH:73][cH:74][cH:75]1.[CH3:25][CH2:26][OH:27].[CH3:76][CH2:77][O:78][C:79](=[O:80])[CH3:81].[CH3:82][CH2:83][N:84]([CH2:85][CH3:86])[CH2:87][CH3:88].[CH:1]1([S:4](=[O:5])(=[O:6])[c:7]2[cH:8][cH:9][c:10]([CH:13]([C:14]([CH:15]=[CH2:16])=[O:17])[CH2:18][CH:19]3[CH2:20][CH2:21][O:22][CH2:23][CH2:24]3)[cH:11][cH:12]2)[CH2:2][CH2:3]1.[Cl-:59].[O:28]1[CH2:29][CH2:30][CH2:31][CH2:32]1>>[CH:1]1([S:4](=[O:5])(=[O:6])[c:7]2[cH:8][cH:9][c:10]([CH:13]([C:14]([CH2:15][CH2:16][C:45]([c:43]3[n:42][n:41][c:40]([CH2:39][O:38][Si:37]([C:33]([CH3:34])([CH3:35])[CH3:36])([c:47]4[cH:48][cH:49][cH:50][cH:51][cH:52]4)[c:53]4[cH:54][cH:55][cH:56][cH:57][cH:58]4)[s:44]3)=[O:46])=[O:17])[CH2:18][CH:19]3[CH2:20][CH2:21][O:22][CH2:23][CH2:24]3)[cH:11][cH:12]2)[CH2:2][CH2:3]1

Participants

9

Reactant 8

HCID 312ChlorideHCID 702EthanolHCID 8028TetrahydrofuranHCID 8471TriethylamineHCID 8857Ethyl AcetateHCID 4253053-Benzyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazol-3-iumHCID 593312584-[4-(cyclopropylsulfonyl)phenyl]-5-(tetrahydro-2H-pyran-4-yl)pent-1-en-3-oneHCID 593316265-({[Tert-butyl(diphenyl)silyl]oxy}methyl)-1,3,4-thiadiazole-2-carbaldehyde

Product 1

HCID 593315691-[5-({[tert-butyl(diphenyl)silyl]oxy}methyl)-1,3,4-thiadiazol-2-yl]-5-[4-(cyclopropylsulfonyl)phenyl]-6-(tetrahydro-2H-pyran-4-yl)hexane-1,4-dione

Sources & evidence

ORD record
ord-fe17d79b9ed8484dbef6326ce0e46d37
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

Loading…