反应详情

At room temperature, 1-hydroxybenzotriazole (184 mg, 1.36 mmol), 1-ethyl-3-[3-(dimethylamino)propyl]carbodiimide hydrochloride (249 mg, 1.30 mmol) and triethylamine (190 μl, 1.36 mmol) were added to an acetonitrile (12 ml) solution of 4-amino-6-fluoro-5-hydroxy-2-methylbiphenyl-3-carbonitrile (I-41) (300 mg, 1.24 mmol) and N-[(benzyloxy)carbonyl]-N-methylglycine (290 mg, 1.30 mmol), followed by stirring at room temperature for 16 hours. The reaction liquid was concentrated under reduced pressure, dissolved in ethyl acetate, and washed with water and saturated brine. After drying over anhydrous sodium sulfate, the insoluble matter was separated by filtration, the residue obtained by concentration was dissolved in xylene (20 ml), then pyridinium p-toluenesulfonate (120 mg) was added, followed by heating under reflux in an oil bath at 160° C. for 6 hours. The reaction liquid was concentrated under reduced pressure, dissolved in ethyl acetate, washed with saturated brine. After drying over anhydrous sodium sulfate, the insoluble matter was separated by filtration, and the residue obtained by filtration was purified by silica gel column chromatography (eluent, n-hexane:ethyl acetate=3:1, v/v) to obtain the entitled compound (242 mg, 46%) as a colorless foamy substance.

1. customThe reaction liquid
2. concentrationwas concentrated under reduced pressure
3. dissolutiondissolved in ethyl acetate
4. washwashed with water and saturated brine
5. dry with materialAfter drying over anhydrous sodium sulfate
6. customthe insoluble matter was separated by filtration
7. customthe residue obtained by concentration
8. temperatureby heating
9. temperatureunder reflux in an oil bath at 160° C. for 6 hours
10. customThe reaction liquid
11. concentrationwas concentrated under reduced pressure
12. dissolutiondissolved in ethyl acetate
13. washwashed with saturated brine
14. dry with materialAfter drying over anhydrous sodium sulfate
15. customthe insoluble matter was separated by filtration
16. customthe residue obtained by filtration
17. customwas purified by silica gel column chromatography (eluent, n-hexane