Water → HCID 19392531, compound

2,2,2-Trifluoroethanol (51.3 ml) in DMF (135 ml) was added to a suspension of sodium hydride (29.5 g) in DMF (335 ml) keeping the temperature below 10° C. After 1 hour the resulting mixture was added to a solution of 2,4-dichloropyrimidine (100 g) in DMF (330 ml) keeping the temperature between -5° and -10° C. 1 Hour later the resulting reaction mixture was poured into water (1 l) and extracted with ethyl acetate (3×400 ml). The combined extracts were washed with brine, dried and concentrated to give 70% pure 2-chloro-4-(2,2,2-trifluoroethoxy)-pyrimidine (142 g) as a pale orange oil; 1H NMR (270 MHz): δ4.78(2H,q), 6.83(1H,d), 8.42(1H,d) ppm.

1. customthe temperature below 10° C
2. customthe temperature between -5° and -10° C
3. custom1 Hour later the resulting reaction mixture
4. extractionextracted with ethyl acetate (3×400 ml)
5. washThe combined extracts were washed with brine
6. customdried
7. concentrationconcentrated

ORD record

ord-ba0d2082334c4582b84f9df4545c058a

Source dataset

uspto-grants-1995_08

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05439910