反应详情

A solution of 15.3 g of 3-methyl-2-nitrophenol in 150 ml of dimethylformamide is combined with 28 g of potassium carbonate and 34.2 g of benzyl bromide, and the mixture is stirred for 3 hours at 70°-80° C. Then the inorganic salts are vacuum-filtered, washed with dichloromethane, and the filtrate evaporated under vacuum. The residue is distilled in a bulb tube at a bath temperature of 120° C. and at 0.01 torr, thus obtaining 23.2 g of 3-benzyloxy-2-nitrotoluene as an oil.

1. filtrationThen the inorganic salts are vacuum-filtered
2. washwashed with dichloromethane
3. customthe filtrate evaporated under vacuum
4. distillationThe residue is distilled in a bulb tube at a bath temperature of 120° C.