反应详情

A solution of Example 35A (200 mg, 0.79 mmol), pyrrolidine (62 mg, 0.869 mmol), ethyldiisopropylamine (224 mg, 1.7 mmol), 1-hydroxy-1H-benzotriazol hydrate (129 mg, 0.95 mmol), 4-N,N-dimethylaminopyridine (1 mg), and 1-ethyl-3-(3-(dimethylamino)propyl)carbodiimide hydrochloride (197 mg, 1.03 mmol) in dimethyl formamide (8 ml) is stirred at room temperature overnight (18 h). The crude reaction mixture is purified directly by preparative RP-HPLC to afford a yellow solid.

1. customThe crude reaction mixture
2. customis purified directly by preparative RP-HPLC
3. customto afford a yellow solid