Iodoethane → HCID 86748352, compound

HRID 1768545Notes

Reaction equation

HRID 1768545 reaction equation
[CH3:1][C:2]1([CH3:9])[S:7][C:6](=[O:8])[NH:5][N:4]=[CH:3]1.[H-].[Na+].[CH2:12](I)[CH3:13]>CN(C)C=O>[CH2:12]([N:5]1[N:4]=[CH:3][C:2]([CH3:9])([CH3:1])[S:7][C:6]1=[O:8])[CH3:13]

Participants

5

Reactant 3

HCID 6340IodoethaneHCID 24758Sodium hydrideHCID 86748353HCID 86748353, compound

Product 1

HCID 86748352HCID 86748352, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A solution of 2.8 g of 5-[1-N-ethyl-3,4-dimethoxybenzimidoyl)-1,2,3,4-tetrahydroquinolin-6-yl]-6,6-dimethyl-3,6-dihydro-2H-1,3,4-thiadiazin-2-one (m.p. 188°) in 40 ml of dimethylformamide is treated with ice-cooling with 0.3 g of NaH and the mixture is stirred for 1 hour. 1.5 ml of ethyl iodide are then added, the mixture is stirred fur a further 2 hours and, after customary working up, 5-[1-N-ethyl-3,4-dimethoxybenzimidoyl)-1,2,3,4-tetrahydroquinolin-6-yl]-3-ethyl-6,6-dimethyl-3,6-dihydro-2H-1,3,4-thiadiazin-2-one is obtained.

Workup

  1. stirringthe mixture is stirred fur a further 2 hours

Sources & evidence

ORD record
ord-c13b10a88b8f45d3b5b1d2c77dc700c9
Source dataset
uspto-grants-1995_01
Patent number
US05378702

Reaction notes

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