Salicylaldehyde → HCID 18948998, compound

HRID 1768614Notes

Reaction equation

HRID 1768614 reaction equation
[Na].[CH:2](=[O:10])[C:3]1[C:4](=[CH:6][CH:7]=[CH:8][CH:9]=1)[OH:5].Cl[CH2:12][CH2:13][O:14][CH2:15][CH2:16][O:17][CH2:18][CH2:19][OH:20]>CN(C)C=O>[OH:20][CH2:19][CH2:18][O:17][CH2:16][CH2:15][O:14][CH2:13][CH2:12][O:5][C:4]1[CH:6]=[CH:7][CH:8]=[CH:9][C:3]=1[CH:2]=[O:10]

Participants

5

Reactant 3

HCID 6998SalicylaldehydeHCID 788712-(2-(2-Chloroethoxy)ethoxy)ethanolHCID 5360545Sodium

Product 1

HCID 18948998HCID 18948998, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A solution of 10 g of sodium salt of salicylaldehyde and 10 g of 2-[2-(2-chloroethoxy)ethoxy]ethanol in dimethylformamide was refluxed for 50 hours. After evaporation, the residue was dissolved in ethyl acetate and the solution washed with water, dried over magnesium sulfate and evaporated. The compound was purified by chromatography (silica; ethyl acetate).

Workup

  1. customAfter evaporation
  2. dissolutionthe residue was dissolved in ethyl acetate
  3. washthe solution washed with water
  4. dry with materialdried over magnesium sulfate
  5. customevaporated
  6. customThe compound was purified by chromatography (silica; ethyl acetate)

Sources & evidence

ORD record
ord-1640a345deb34f44aeb9c1c33ceb028c
Source dataset
uspto-grants-1995_01
Patent number
US05378718

Reaction notes

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