1,1'-Carbonyldiimidazole → HCID 86296966, compound

HRID 1773726Notes

Reaction equation

HRID 1773726 reaction equation
C1N=CN([C:6](N2C=NC=C2)=[O:7])C=1.[NH2:13][C:14]1[C:19]([NH2:20])=[CH:18][C:17]([C:21]2[C:22]([CH3:27])=[N:23][O:24][C:25]=2[CH3:26])=[CH:16][C:15]=1[C:28]([C:36]1[CH:41]=[CH:40][CH:39]=[CH:38][N:37]=1)([C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][N:31]=1)[OH:29]>C1COCC1.O.C(OCC)(=O)C>[CH3:27][C:22]1[C:21]([C:17]2[CH:16]=[C:15]([C:28]([OH:29])([C:30]3[CH:35]=[CH:34][CH:33]=[CH:32][N:31]=3)[C:36]3[CH:41]=[CH:40][CH:39]=[CH:38][N:37]=3)[C:14]3[NH:13][C:6](=[O:7])[NH:20][C:19]=3[CH:18]=2)=[C:25]([CH3:26])[O:24][N:23]=1

Participants

6

Reactant 2

HCID 682631,1'-CarbonyldiimidazoleHCID 117601099HCID 117601099, compound

Product 1

HCID 86296966HCID 86296966, compound

Reagents, catalysts & solvents 3

HCID 962WaterSolventHCID 8028TetrahydrofuranSolventHCID 8857Ethyl AcetateSolvent

Procedure

CDI (1.1 g, 6 mmol) was added to a solution of (2,3-diamino-5-(3,5-dimethylisoxazol-4-yl)phenyl)di(pyridin-2-yl)methanol (1.43 g, 3.7 mmol) in THF (10 mL) and the reaction mixture was stirred for 3 days. The reaction mixture was diluted with 100 mL water and 100 mL ethyl acetate and sonicated and filtered to yield the desired product.

Workup

  1. customsonicated
  2. filtrationfiltered

Sources & evidence

ORD record
ord-206dc4a6b84749cba507317b2dfab6e6
Source dataset
uspto-grants-2016_02
Patent number
US09255089B2

Reaction notes

Loading…