Pyrrole → HCID 10678999, compound

HRID 1781152Notes

Reaction equation

HRID 1781152 reaction equation
[NH:1]1[CH:5]=[CH:4][CH:3]=[CH:2]1.Br[CH2:7][C:8]1[CH:15]=[CH:14][C:11]([C:12]#[N:13])=[CH:10][CH:9]=1>CN(C=O)C>[C:12]([C:11]1[CH:14]=[CH:15][C:8]([CH2:7][N:1]2[CH:5]=[CH:4][CH:3]=[CH:2]2)=[CH:9][CH:10]=1)#[N:13]

Participants

4

Reactant 2

HCID 8027PyrroleHCID 869964-(Bromomethyl)benzonitrile

Product 1

HCID 10678999HCID 10678999, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Using pyrrole and 4-(bromomethyl)benzonitrile and the method of Example 53A, except using DMF as the solvent, provided N-(4-cyanobenzyl)pyrrole. 1H NMR (CDCl3) δ 7.62 (m, 2H), 7.14 (m, 2H), 6.69 (m, 2H), 6.24 (m, 2H), 5.15 (s, 2H). MS (DCl/NH3) m/e 183 (M+H)+, 200 (M+H+NH3)+.

Sources & evidence

ORD record
ord-a164abf20dbc49c9b6d478b635237038
Source dataset
uspto-grants-1997_05
Patent number
US05631401

Reaction notes

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