反应详情

温度

0 °C

4.9 ml of (2-methoxyethoxy)-acetic acid is dissolved in 500 ml of tetrahydrofuran. 9.7 ml of triethylamine and 5.6 ml of isobutyl chloroformate are added at 0° C., and it is stirred for 30 minutes at 0° C. 3.96 g of 2,6-diaminopyridine is added, and it is stirred for another 4 hours at room temperature. The reaction mixture is mixed with semi-saturated sodium bicarbonate solution and extracted with ethyl acetate. The organic solution is washed with saturated sodium chloride solution, dried on sodium sulfate, concentrated by evaporation, and after purification by chromatography on silica gel, 5.04 g of the title compound is obtained.

1. stirringit is stirred for another 4 hours at room temperature
2. extractionextracted with ethyl acetate
3. washThe organic solution is washed with saturated sodium chloride solution
4. customdried on sodium sulfate
5. concentrationconcentrated by evaporation
6. customafter purification by chromatography on silica gel