反应详情

温度

90 °C

A mixture of 1.81 g of N-methyl-2-{2-(2-chloroethyloxy)phenyl]thiazolidine-3-carboxamide, 0.97 g of N-phenylpiperazine, 0.83 g of potassium carbonate, 0.90 g of sodium iodide and 25 ml of dimethylformamide is stirred at 90° C. for 18 hours. The mixture is concentrated under reduced pressure to remove solvent. Water is added to the residue, and the aqueous mixture is extracted with ethyl acetate. The extract is washed with water, dried and then concentrated under reduced pressure to remove solvent. The residue is crystallized with isopropyl ether, and the crystals are recrystallized from a mixture of ethyl acetate and n-hexane. 1.48 g of N-methyl-2-{2-[2-(4-phenylpiperazin-1-yl)ethyloxy]phenyl}thiazolidine-3-carboxamide are obtained. Yield: 57.8%

1. concentrationThe mixture is concentrated under reduced pressure
2. customto remove solvent
3. additionWater is added to the residue
4. extractionthe aqueous mixture is extracted with ethyl acetate
5. washThe extract is washed with water
6. customdried
7. concentrationconcentrated under reduced pressure
8. customto remove solvent
9. customThe residue is crystallized with isopropyl ether
10. customthe crystals are recrystallized from a mixture of ethyl acetate and n-hexane